Jebrell Glover Associate Professor Office: Seeley G. Mudd Bldg. Room: 612 Phone: 85081  kjg206@lehigh.edu

Glover Research Group

Research Interests:

Our broad interests lie in addressing the fundamental questions surrounding the interactions of lipid bilayers with proteins. Using various biophysical techniques namely NMR and analytical ultracentrifugation, we aim to understand the behavior of proteins in the lipid milieu on a molecular level. Our research capitalizes on the use of bicelles, a "native-like" membrane mimic which has great potential to overcome some of the hurdles that have limited the study of membrane proteins.

Teaching Interests:

Biochemistry and biophysical chemistry.

Recent Publications:

Zhang J., Li D., Liu G., Glover K. J., Liu T., The Lag Periods During the Self-Assembly of   {Mo72Fe30} Macroions: Connection to the Virus Capsid Formation Process.  J. Am. Chem. Soc. 2009, 131, (42), 15152-9.

Diefenderfer C., Lee J., Mlyanarski S., Guo Y., Glover K. J., Reliable expression and purification of highly insoluble transmembrane domains.  Anal Biochem. 2009, 384, (2), 274-8.

Chen, M. M.; Glover, K. J.; Imperiali, B., From Peptide to Protein: Comparative Analysis of the Substrate Specificity of N-Linked Glycosylation in C. jejuni.  Biochemistry 2007, 46, (18), 5579-85.

Glover, K. J.; Weerapana, E.; Chen, M. M.; Imperiali, B., Direct biochemical evidence for the utilization of UDP-bacillosamine by PglC, an essential glycosyl-1-phosphate transferase in the Campylobacter jejuni N-linked glycosylation pathway. Biochemistry 2006 , 45, (16), 5343-5350.

Glover, K. J.; Weerapana, E.; Numao, S.; Imperiali, B., Chemo-Enzymatic Synthesis of Glycopeptides Using PglB, a Bacterial Oligosaccharyl Transferase from Campylobacter Jejuni . Chem. Biol. 2005 , 12, (12), 1311-1315.

Weerapana, E.; Glover, K. J.; Chen, M. M.; Imperiali, B., Investigating Bacterial N -Linked Glycosylation: Synthesis and Glycosyl Acceptor Activity of the Undecaprenylpyrophosphate-Linked Bacillosamine. J. Am. Chem. Soc. 2005 , 127, (40), 13766-13767.

Glover, K. J.; Weerapana, E.; Imperiali, B., In Vitro Assembly of the Undecaprenylpyrophosphate-Linked Heptasaccharide for Prokaryotic N -Linked Glycosylation. Proc. Natl. Acad. Sci. U.S.A. 2005 , 102, (40), 14255-14259.

Whiles, J. A.; Glover, K. J.; Vold, R. R.; Komives, E. A., Methods for Studying Transmembrane Peptides in Bicelles: Consequences of Hydrophobic Mismatch and Peptide Sequence. J. Magn. Reson. 2002, 158, (1-2), 149-156.

Glover, K. J.; Whiles, J. A.; Vold, R. R.; Melacini, G., Position of Residues in Transmembrane Peptides with Respect to the Lipid Bilayer: A Combined Lipid NOEs and Water Chemical Exchange Approach in Phospholipid Bicelles. J. Biomol. NMR 2002, 22, (1), 57-64.